@article{García López_Bermejo-De la Calzada_Galajares-Cabada_Castro-Martín_2023, title={Adding oral medication does not have any benefit on natural-cycle ivf results.}, volume={40}, url={/index.php/rif/article/view/83}, abstractNote={&lt;p&gt;&lt;u&gt;Introduction:&lt;/u&gt; In recent years, natural cycle IVF and minimal ovarian stimulation IVF had been under- going a revival, gaining recognition as safer, cheaper, and more comfortable options for patients. We define natural cicle IVF as the treatment in which oocytes are obtained from a spontaneous ovulatory cycle. When oral drugs are used (usually clomiphene citrate or letrozole), the process is referred to as minimal ovarian stimulation cycle IVF. The aim of this study is to clarify whether the introduction of oral medication is beneficial for patients.&lt;/p&gt;
&lt;p&gt;&lt;u&gt;Methods:&lt;/u&gt; We retrospectively analysed all natural or minimal ovarian stimulation IVF treatments that took place in our clinic during the studied period (January 2016 - December 2020). Descriptive variables were analysed with a t-test, and a chi-square test was performed on result variables.&lt;/p&gt;
&lt;p&gt;&lt;u&gt;Results:&lt;/u&gt; We found significant differences, between both protocols, in the number of oocytes obtained after oocyte retrieval (1.03 vs 1.63, p&amp;lt;0.001), number of mature oocytes (0.9 vs 1.3, p &amp;lt; 0.01), fertilized oocytes (0.7 vs 1.1, p &amp;lt; 0.01), and number of embryos available for transfer (0.5 vs 0.7, p &amp;lt; 0.01).Howe- ver, we did not found signficant differences in terms of pregnancy rate (26,3% vs 19,6%, p=0.251) or live birth rate (16.3% vs 14,3%, p=0.7806).&lt;/p&gt;
&lt;p&gt;&lt;u&gt;Discusion:&lt;/u&gt; Adding oral medication to natural cycle IVF does not seem to have an impact on the clinical &lt;span style=&quot;font-family: ’Noto Sans’, ’Noto Kufi Arabic’, -apple-system, BlinkMacSystemFont, ’Segoe UI’, Roboto, Oxygen-Sans, Ubuntu, Cantarell, ’Helvetica Neue’, sans-serif;&quot;&gt;results of the cycle. More studies are necessary, but we could reconsider the need to add oral medica- tion since they suppose a higher cost for the patient.&lt;/span&gt;&lt;/p&gt;}, number={1 Enero-Febrero-Marzo-Abril}, journal={Revista Iberoamericana de Fertilidad y Reproducción Humana}, author={García López, Enrique and Bermejo-De la Calzada, Alfonso and Galajares-Cabada, Nereida and Castro-Martín, Bárbara}, year={2023}, month={May} }