@article{Martínez Salazar_2023, title={Genetic modified Endometrial Mesenchymal Stem Cells as a Cellular Therapy for Endometriosis}, volume={40}, url={/index.php/rif/article/view/81}, abstractNote={<p>A review and integration of three fundamental concepts that are currently of high scientific and biomedical interest is proposed: endometriosis, Endometrial Mesenchymal Stem Cells and their genetic modification to be used as cell therapy in this pathology. Endometriosis is a chronic, benign gynecological disease characterized by the ectopic formation of endometrial stroma and glands, mainly in the pelvic peritoneum. It affects between 6-15% of women in reproductive age with important consequences on their physical, reproductive and mental health. It has been established an important participation of endometrial stem cells within its causes, which is why they become a significant therapeutic target. It has been reported multiple characteristics that support Endometrial Mesenchymal Stem Cells as the optimal model for their use in cell therapy: defined characterization, migration capacity and co-location in the lesion, paracrine and juxtacrine action, immunomodulatory action, modulator action of angiogenesis and apoptosis, low tumorigenicity, transdifferentiation capacity, among others, and the specific use of menstrual blood stem cells is proposed because their easy obtaining, characterization and cell culture. It has been described that these stem cells have a dynamic and dual behavior, in the sense that they can contribute both to the formation of a lesion and to its modulation, for which, a better understanding of their activity is proposed before their direct use and, to mitigate this dynamic cellular behavior, it is proposed that cell therapy employ a strategy of genetic modification of cells for the expression of factors relevant to the treatment of endometriotic lesions and that have an antiproliferative, immunomodulatory action. Finally, reference is made to the need to continue with further research and deepening in the knowledge and understanding of these fundamental concepts and their possible use in cell therapy.</p>}, number={1 Enero-Febrero-Marzo-Abril}, journal={Revista Iberoamericana de Fertilidad y Reproducción Humana}, author={Martínez Salazar, Mauricio}, year={2023}, month={May} }